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Extend the selection to the last cell down

Windows shortcut 
CtrlShift
Mac shortcut 

If the active cell is empty, Excel will extend the selection to the first non-empty cell below the active cell. If the active cell is non-empty, Excel will extend the selection on the last non-empty cell below the active cell. On a Mac, the command key (⌘) can be used instead of the control key.

Related videos

The videos below demonstrate this shortcut.
This video shows how to use VLOOKUP to merge data in two tables based on a common ID. You can even use this technique to reorder the columns you retrieve.
In this video, we'll look at how to apply conditional formatting to one cell based on values in another, using a formula.
In this video, we'll look at how to use conditional formatting to shade every other row in a table. This is sometimes called "zebra striping".
In this video, we'll look at a few ways to generate random values with the RANDBETWEEN function, including random dates, random prices, and random workdays.
In this video, we compare formulas and pivot tables side-by-side to build the same reports to demonstrate how powerful and easy to use pivot tables are.